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Indications and usage:
Desyrel (Trazodone Hydrochloride) is a selective serotonin reuptake inhibitor indicated for the treatment of major depressive disorder (MDD).
Dosage and administration:
Dosage forms and strengths:
Desyrel (Trazodone Hydrochloride) scored tablets: 25 mg, 50 mg, 100 mg, 150 mg and 300 mg.
Death from overdose has occurred in patients ingesting Desyrel and other CNS depressant drugs concurrently (alcohol, alcohol and chloral hydrate and diazepam, amobarbital, chlordiazepoxide, or meprobamate).
The most severe reactions reported to have occurred with overdose of Trazodone HCl alone have been priapism, respiratory arrest, seizures, and ECG changes, including QT prolongation. The reactions reported most frequently have been drowsiness and vomiting. Overdosage may cause an increase in incidence or severity of any of the reported adverse reactions.
There is no specific antidote for trazodone hydrochloride overdose. In managing overdosage, consider the possibility of multiple drug involvement. For current information on the management of poisoning or overdose, contact a local poison control center.
Concomitant use of trazodone and monoamine oxidase inhibitors (MAOIs), or use within 14 days of stopping MAOIs.
Warnings and precautions:
Side effects, adverse reactions:
Most common adverse reactions of trazodone (incidence >= 5% and twice that of placebo) are: edema, blurred vision, syncope, drowsiness, fatigue, diarrhea, nasal congestion, weight loss.
To report suspected adverse reactions, contact Pragma Pharmaceuticals LLC or your local FDA.
Patient counseling information:
Suicidal thoughts and behaviors
Advise patients and caregivers to look for the emergence of suicidality, especially early during treatment and when the dosage is adjusted up or down and instruct them to report such symptoms to the healthcare provider.
Dosage and administration
Advise patients that Desyrel (Trazodone Hydrochloride) tablets should be taken shortly after a meal or light snack. Advise patients regarding the importance of following dosage titration instructions.
Caution patients about the risk of serotonin syndrome, particularly with the concomitant use of Desyrel with other serotonergic drugs including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, St. John's Wort, and with drugs that impair metabolism of serotonin (in particular, MAOIs, both those intended to treat psychiatric disorders and also others, such as linezolid). Patients should contact their health care provider or report to the emergency room if they experience signs or symptoms of serotonin syndrome.
Activation of mania/hypomania
Advise patients and their caregivers to observe for signs of activation of mania/hypomania and instruct them to report such symptoms to the healthcare provider.
Increased risk of bleeding
Inform patients about the concomitant use of trazodone with aspirin, NSAIDs, other antiplatelet drugs, warfarin, or other anticoagulants because the combined use of drugs that interfere with serotonin reuptake and these medications has been associated with an increased risk of bleeding. Advise them to inform their health care providers if they are taking or planning to take any prescription or over-the-counter medications that increase the risk of bleeding.
Advise patients not to abruptly discontinue Trazodone HCl and to discuss any tapering regimen with their healthcare provider. Adverse reactions can occur when Desyrel is discontinued.
Advise patients to inform their health care providers if they are taking, or plan to take any prescription or over-the-counter medications since there is a potential for interactions.
Use in specific populations:
Based on animal data, may cause fetal harm.
Use trazodone pills with caution.
Where to buy trazodone online:
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