Buy Trazodone (Desyrel) tablets online

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Indications and usage:

Desyrel (Trazodone Hydrochloride) is a selective serotonin reuptake inhibitor indicated for the treatment of major depressive disorder (MDD).


Dosage and administration:

  • Starting dose: 150 mg in divided doses daily. May be increased by 50 mg per day every three to four days. Maximum dose: 400 mg per day in divided doses.
  • Desyrel should be taken shortly after a meal or light snack.
  • Tablets should be swallowed whole or broken in half along the score line.
  • When trazodone is discontinued, gradual dose reduction is recommended.


    Dosage forms and strengths:

    Desyrel (Trazodone Hydrochloride) scored tablets: 25 mg, 50 mg, 100 mg, 150 mg and 300 mg.


    Overdosage:

    Death from overdose has occurred in patients ingesting Desyrel and other CNS depressant drugs concurrently (alcohol, alcohol and chloral hydrate and diazepam, amobarbital, chlordiazepoxide, or meprobamate).

    The most severe reactions reported to have occurred with overdose of Trazodone HCl alone have been priapism, respiratory arrest, seizures, and ECG changes, including QT prolongation. The reactions reported most frequently have been drowsiness and vomiting. Overdosage may cause an increase in incidence or severity of any of the reported adverse reactions.

    There is no specific antidote for trazodone hydrochloride overdose. In managing overdosage, consider the possibility of multiple drug involvement. For current information on the management of poisoning or overdose, contact a local poison control center.


    Contraindications:

    Concomitant use of trazodone and monoamine oxidase inhibitors (MAOIs), or use within 14 days of stopping MAOIs.


    Warnings and precautions:

  • Serotonin Syndrome: increased risk when co-administered with other serotonergic agents (e.g., SSRI, SNRI, triptans), but also when taken alone. If it occurs, discontinue Desyrel and initiate supportive treatment.
  • Cardiac Arrhythmias: increases the QT interval. Avoid use with drugs that also increase the QT interval and in patients with risk factors for prolonged QT interval.
  • Orthostatic Hypotension and Syncope: warn patients of risk and symptoms of hypotension.
  • Increased Risk of Bleeding: concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk.
  • Priapism: cases of painful and prolonged penile erections and priapism have been reported. Immediate medical attention should be sought if signs and symptoms of prolonged penile erections or priapism are observed.
  • Activation of Mania or Hypomania: screen for bipolar disorder and monitor for mania or hypomania.
  • Potential for Cognitive and Motor Impairment: has potential to impair judgment, thinking, and motor skills. Advise patients to use caution when operating machinery.
  • Angle-Closure Glaucoma: avoid use of antidepressants, including Desyrel (Trazodone Hydrochloride) tablets, in patients with untreated anatomically narrow angles.


    Side effects, adverse reactions:

    Most common adverse reactions of trazodone (incidence >= 5% and twice that of placebo) are: edema, blurred vision, syncope, drowsiness, fatigue, diarrhea, nasal congestion, weight loss.

    To report suspected adverse reactions, contact Pragma Pharmaceuticals LLC or your local FDA.


    Drug interactions:

  • CNS Depressants: Desyrel may enhance effects of alcohol, barbiturates, or other CNS depressants.
  • CYP3A4 Inhibitors: consider trazodone dose reduction based on tolerability.
  • CYP3A4 Inducers: increase in Desyrel dosage may be necessary.
  • Digoxin or Phenytoin: monitor for increased digoxin or phenytoin serum levels.
  • Warfarin: monitor for increased or decreased prothrombin time.

    Related medications:

  • Buspirone (Buspar)
  • Selegiline (Eldepryl, Emsam)


    Patient counseling information:

    Suicidal thoughts and behaviors

    Advise patients and caregivers to look for the emergence of suicidality, especially early during treatment and when the dosage is adjusted up or down and instruct them to report such symptoms to the healthcare provider.

    Dosage and administration

    Advise patients that Desyrel (Trazodone Hydrochloride) tablets should be taken shortly after a meal or light snack. Advise patients regarding the importance of following dosage titration instructions.

    Serotonin syndrome

    Caution patients about the risk of serotonin syndrome, particularly with the concomitant use of Desyrel with other serotonergic drugs including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, St. John's Wort, and with drugs that impair metabolism of serotonin (in particular, MAOIs, both those intended to treat psychiatric disorders and also others, such as linezolid). Patients should contact their health care provider or report to the emergency room if they experience signs or symptoms of serotonin syndrome.

    Activation of mania/hypomania

    Advise patients and their caregivers to observe for signs of activation of mania/hypomania and instruct them to report such symptoms to the healthcare provider.

    Increased risk of bleeding

    Inform patients about the concomitant use of trazodone with aspirin, NSAIDs, other antiplatelet drugs, warfarin, or other anticoagulants because the combined use of drugs that interfere with serotonin reuptake and these medications has been associated with an increased risk of bleeding. Advise them to inform their health care providers if they are taking or planning to take any prescription or over-the-counter medications that increase the risk of bleeding.

    Discontinuation syndrome

    Advise patients not to abruptly discontinue Trazodone HCl and to discuss any tapering regimen with their healthcare provider. Adverse reactions can occur when Desyrel is discontinued.

    Concomitant medications

    Advise patients to inform their health care providers if they are taking, or plan to take any prescription or over-the-counter medications since there is a potential for interactions.


    Use in specific populations:

    Pregnancy

    Based on animal data, may cause fetal harm.

    Nursing Mothers

    Use trazodone pills with caution.


    Where to buy trazodone online:

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